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Possibly, its function of pumping non-metabolized xenobiotics out of the cell and back into the intestinal lumen, may allow more opportunities for phase I activity to metabolize the xenobiotic before it is taken into circulation

doi: 10.1016/j.bbi.2019.03.004 97 LaneLCCheethamTDPerrosPPearceSHS

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The condition affects the brains smallest blood vessels and leads to a cascade of pathological changes that contribute to vascular cognitive impairment, stroke, gait dysfunction, and disability