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Jan 1 2018;187(1):60-74

These residues can undergo oxidation to form disulphide bonds and thus reduce PDI or an equivalent ER oxidoreductase

It plays a vital role in neutralizing free radicals, enhancing immunity, and promoting liver function

In many cases, its associated with high levels of ongoing stress, a history of stressful events such as PTSD, sleep deprivation, or other illnesses, such as the flu