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Nrf2 displays both pro- and anti-atherogenic effects in experimental animal models, and the Nrf2 pathway becomes a promising target for atherosclerosis prevention (234)

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Since SARS-CoV-2 activates mitochondrial ROS-mediated feedback loops that produce long-term changes in the redox status and endothelial function of the host, leading to cardiovascular disease and lung injury (Chang et al., 2021), and endothelial cells are key players in inflammatory pathologies, such as acute respiratory distress syndrome, thrombosis, and atherosclerosis

References Stockwell, B

Insulin effects in muscle and adipose tissue

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