While IGF-1 has important physiological functions, elevated levels carry potential concerns including increased cell proliferation that may support tumor growth in individuals with cancer or pre-cancerous conditions, accelerated aging processes through growth pathway activation, potential cardiovascular effects with chronic elevation, and metabolic consequences including effects on glucose and lipid metabolism
Vasodilation: Blood vessels near the skins surface widen, helping dissipate heat and improve blood flow through your limbs
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In addition, with aging, the production and release of renin is reduced, so the total aldosterone level is also reduced, and the renin-angiotensin system (RAS) within the kidney and throughout the body is suppressed (Karam and Tuazon, 2013)
Cell Death Dis (2020) 11(2):125
So is considered well-tolerated and safe
