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doi: 10.1080/10245332.2017.1375064

Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury

Oral bioavailability ranges from 4060%, making subcutaneous or intranasal routes theoretically more efficient, though fewer published studies use those delivery methods

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The activation of NRF-2 in liver suppresses the synthesis of fatty acids [70], as observed in this study that included experimental feeding with 8-week-old NRF-2 null mice, and wild-type mice fed experimentally, observing the mRNA of sterol regulatory element-binding protein 1-c and fatty acid synthase as highly expressed in NRF-2 null [71], concluding that the protective action is afforded by the increase of AR