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Safe combinations of allergy medications You can safely combine medications that work differently, for example: Oral antihistamine (Claritin, Allegra, Zyrtec) with a steroid nasal spray (Rhinocort, Flonase) Oral antihistamine plus a decongestant nasal spray or oral decongestant if needed ZyrtecD (cetirizine/pseudoephedrine) for congestion, unless you have high blood pressure or heart disease Timing between Zyrtec and Benadryl Zyrtec lasts up to 24 hours