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Nrf2 is released from the Nrf2Keap1 system and then translocates to the cell nucleus, where it combines with small musculoaponeurotic fibrosarcoma (sMAF) proteins to form heterodimers

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Other factors are most likely involved, such as a protective effect of Gln on the epithelial barrier

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In fact, GR and FK506 binding protein 5 (FKBP5) expression can be changed by the polyphenolic flavonoid icariin, which enhances GR stability and lessens GR sensitivity to GC in vivo (167)

If you struggle with these symptoms, have IBS, SIBO, or other gut problems, avoid brands that contain high-FODMAP ingredients and leave them out of your homemade bone broth