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Maheshwari et al., 2022)

What the STEP 4 data makes clear is that weight regain is a real possibility after stopping the medication, which is why a long-term maintenance strategy matters

Instead, it can unmask a latent predisposition or trigger a flare in an already vulnerable individual by creating the perfect metabolic storm: a sudden uric acid surge from weight loss combined with potential dehydration

We understand that health concerns don't always follow a convenient schedule

"So, we generally start with those changes first, and then you intervene with the pharmacological treatment," Gill said.

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