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GLP-1 and SGLT-2 have the highest level of clinical evidence for use in this population, per the American Diabetes Association (ADA) guidelines.[3] Both GLP-1 and SGTL-2 products, such as Jardiance, have the ability to improve blood glucose control (hemoglobin A1c reduction), potentiate weight loss and provide a cardiovascular protective effect
doi: 10.1016/j.cell.2020.02.058 3 GarcaLF
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Intervention with ferroptosis inhibitors such as ferrostatin-1 and deferoxamine has been shown to restore chondrocyte viability, reduce MMP13 and ADAMTS5 expression, and partially rescue extracellular matrix loss, suggesting that inhibiting ferroptosis may mitigate OA cartilage injury (54, 55)
GHK-Cu blocks ferritin channels and the release of tissue-damaging free (oxidative) iron after injury, thus blocking iron-catalyzed lipid peroxidation that often occurs after injury and interleukin-1 damage to pancreatic islet cells
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