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By activating GLP-1 receptors in the hypothalamus and brainstem, these analogs promote satiety, leading to reduced food intake and weight loss ( Studies as Network Meta-analysis and clinical trials have shown that GLP1-RA can achieve a statistically significant decrease in HbA1C compared to placebo, as well as a weight reduction ranging between 1.3 and 8.65 kg ( With regard to cardioprotection, several mechanisms have been proposed

Bunkelmann and Trelease, 1999)

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The study appears in According to the GLP-1 drugs also improve blood flow to the heart and act directly on the hypothalamus to increase the sensation of being full after a meal

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