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The activation of cAMP-PKA signaling in gut IELs can inhibit the phosphorylation of Zeta-chain-associated protein kinase-70 (ZAP-70), stopping the signal from TCR, resulting in the inhibition of the immunological response of T cells (Wong et al., 2022

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Moreover, basic local alignment search tool (BLAST) searches against the Human Expressed Sequence Tag (EST) database indicated a mitochondrial DNA origin for MOTS-c and ruled out a nuclear origin [7]

Vitamin D also regulates the expression and release of serine proteases such as kallikrein-5/7 in keratinocytes, thereby facilitating the cleavage of the precursor protein HCAP18 into smaller active peptides [242]