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For one, hyperhomocysteinemia has been known to be associated with insufficient stimulation of CBS activity (Selhub et al., 12 deficiency, methionine block implies that SAM (driven by Met) is lowered as well and hence it is plausible CBS is less effective

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The drug, used alongside a reduced calorie diet and increased physical activity, was the first approved drug for chronic weight management in adults with obesity or who are overweight since 2014

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