glp-1 bad GLP-1s, taste and what's happening to our diets Multifaceted Roles of GLP-1 and

doi: 10.2337/db13-0893 168 BergmannNCGasbjergLSHeimbrgerSMKroghLSLDelaFHartmannBet al

23 The FDA recommends that patients remain on each dose of certain GLP-1 RA therapies, namely semaglutide, dulaglutide, and tirzepatide, for at least 4 weeks before dose increases

Sarcopenia Approximately 40% of the weight reduction associated with GLP-1 RAs is derived from a lean body mass, which raises significant concerns regarding its potential negative impact on skeletal muscle functionality [110]

doi:10.1002/dmrr.553 12

Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake

Tirzepatide (Zepbound) was another drug assessed in a study conducted in New England Journal of Medicine for weight loss in individuals with obesity