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Coverage decisions often require documentation from the prescribing physician demonstrating medical necessity and failed lifestyle interventions

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Yang et al., 2025)

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"Instead, it has remained remarkably robust, raising important questions about how these products are regulated and how patients can know whether they're receiving medications that meet appropriate quality standards." Compounded GLP-1 drugs expanded rapidly during nationwide shortages of Wegovy and Zepbound, when federal regulations temporarily allowed pharmacies to compound copies of medications in short supply

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