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4.2.2 Iron deposition and mitochondrial dysfunction Since the discovery of ferroptosis in 2012, mitochondria have been proposed to play a crucial role in regulating erastin-induced ferroptosis ( 2+ levels promote ROS production via the Fenton reaction, ultimately inducing cell ferroptosis

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It was first described in research as an exercise-mimetic a compound that activates some of the same cellular pathways triggered by physical activity, even in sedentary states

But that qualifier the ones with actual evidence is doing a lot of heavy lifting in that sentence

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