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The authors also found that the glycine-amidated conjugates of the BAs and deoxycholic acid (DCA) increased more than the taurine conjugates, resulting in a more hydrophobic pool of BAs, which as noted above are more cytotoxic (Deo and Bandiera 2008)

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These drugs exert their effects by inhibiting the thiazide-sensitive Na + /Cl cotransporter identified as NCC (also identified as NCCT: encoded by the SLC12A3 gene)