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Diabetes Obes Metab (2020) 12:80111

Mostafa et al

doi: 10.1128/IAI.01725-07 179 LinH.-H

Rare Na V 1.7 variants associated with painful diabetic peripheral neuropathy

Furthermore, L-carnitine upregulates genes involved in fatty acid transport and mitochondrial -oxidation ( Octn2, Cpt1a, Cpt2, Acadm ) while increasing metabolites associated with TCA cycle, urea cycle, and antioxidant pathways (malate, citrulline) (45)