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GSH can conjugate with DAQs to form GSH-DAQ conjugates, evidenced by the detection of various GSH-DAQ conjugates in post-mortem PD brains [5, 150, 154,155,156]
Bioinformatics 30 , 923930 (2014)
[25] [26] [27] Metabolism [edit] Among the many metabolic processes in which it participates, glutathione is required for the biosynthesis of leukotrienes and prostaglandins
The antioxidant activity of GSH intermediated via thiol (-SH) of its cysteine residue upon its interaction with ROS or electrophiles and the GSH oxidized to GSSG (oxidized Glutathione), the GSSG will reduce to GSH by Glutathione reductase (GR), the activity of GR is therefore very important to keep the antioxidant power of mammalian cells, while GSH/GSSG ratio is an indicator for redox balance in the cell