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Alcohol should be minimised during retatrutide treatment as it can worsen nausea, impair blood glucose regulation, and increase the risk of hypoglycaemia in people also taking insulin or sulfonylureas

PMID: 9209650

Cell 19 , 9941006 (2008)

Weight Regain Risk: Studies (e.g., Axios , Verywell Health ) show many regain 50-70% of lost weight within a year due to a slower metabolism and returning habits