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Patients who escalate doses too rapidly or skip the recommended titration schedule are more likely to experience prolonged or severe gastrointestinal symptoms

Two major studies published in 2025 found: Marathe et al

Tirzepatide delivers substantially greater weight loss (20.9% vs 12.4%) through its dual GIP/GLP-1 mechanism and is FDA-approved with a large evidence base

However, it is reasonable to consider what is known from related drug classes

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