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Iron metabolism plays a central role, as excessive intracellular iron promotes the Fenton reaction, generating lethal amounts of ROS that drive lipid peroxidation [4]

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911,13,14 Organelle swelling leads to cellular necrosis and the release of mitochondrial contents, such as apoptosis-inducing factor (AIF) and endonuclease G (EndoG), which in turn migrate to the nuclei and cause DNA fragmentation

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