You should contact your GP or diabetes care team if: Cold sensitivity is severe, persistent, or progressively worsening You experience cold intolerance accompanied by other symptoms such as extreme fatigue, constipation, dry skin, hair loss, or unexplained weight gain You develop symptoms suggestive of hypothyroidism (underactive thyroid), which can cause cold sensitivity (note that while GLP-1 receptor agonists have been associated with C-cell tumours in rodent studies, there is no established link to hypothyroidism in humans) You notice signs of anaemia, such as pallor, breathlessness, or palpitations, which can cause cold sensitivity Cold hands or feet are accompanied by colour changes (white, blue, or red), pain, or numbness, which may indicate circulatory problems You experience unexplained fever, chills, or rigors, which could suggest infection You have symptoms of hypoglycaemia (low blood sugar) such as shakiness, sweating, or confusion, especially if you also take insulin or sulfonylureas NICE guidance (NG28) recommends regular monitoring of patients on GLP-1 receptor agonists, including assessment of glycaemic control, weight, and tolerability
[3] Key Takeaways Comparable to injectable: 16.6% weight loss is similar to injectable Wegovy (14.9%) High responder rate: 76% of patients lost at least 5% of body weight Clinically meaningful: Half achieved 15%+ weight loss CV benefits preserved: Also approved for cardiovascular risk reduction The Bottom Line Oral Wegovy delivers weight loss results comparable to the injectableproving the pill form works just as well for most patients
Injection-site reactions Mild redness or tenderness at the injection site is possible, though usually short-lived
What actually matters is whether the ingredients in Replenza are the right ones, at the right dosages, to address GLP-1 nutrient depletion
Follow-up visits are another charge too
The key difference is intention: titration aims to find your dose, while maintenance aims to sustain your results
