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In AD, CryAB is upregulated in the brain and colocalizes with amyloid- within extracellular senile plaques

These medications may reduce binge eating disorders or even have a role in treating substance use disorders

Based on the results we and others have observed in wild-type mice 12,55 , we hypothesize that fasting may be sufficient to recapitulate many of the benefits of CR on cognition and AD pathology, but this has not been tested