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Clinical trials also confirm steady weight loss and better blood sugar by 12 weeks

Tirzepatide, a dual glucagon-like peptide-1 (GIP) and GLP-1RAs, administered once weekly at a 15 mg dose, resulted in an average weight loss of 20.9% over 72 weeks (Jastreboff et al., 2022), driven by its synergistic effects on appetite regulation, energy intake reduction, and fat mass decrease (Heise et al., 2023)

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Overexpression of BHMT not only repressed the expression of many mesenchymal markers but also induced the expression of two epithelial markers that were repressed in siHNF4 cells (Fig