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Because the 5-day half-life means roughly 50% of the drug remains at Day 5 and about 25% at Day 10, some receptor occupancy persists even through a skipped week

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Men using tirzepatide in clinical trials experienced average weight losses of 2022% of body weight over 68 weeks

But the volume is arriving now, and the operational decisions being made today will determine the impact of that volume on margins over the next three to five years

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