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For severe deficiency, clinicians typically prescribe loading doses daily or every other day for one to two weeks followed by monthly maintenance injections

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The indication, dose, insurance coverage, and medical appropriateness depend on the specific medication and patient

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Stimulation of NO production via the NOS-dependent pathway nNOS and eNOS are calciumcalmodulin-dependent enzymes responsible for the conversion of L-arginine and oxygen to L-citrulline and NO (Ignarro, 1990