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GIP activation may additionally potentiate the insulin secretion effects of GLP-1 activation on the pancreas and the weight loss effects of GLP-1 activation on CNS [13]
However, for patients with chronic kidney disease (CKD) , these medications require careful dosing to avoid risks like dehydration, electrolyte imbalances, and acute kidney injury
The appetite suppressant effect is now very mild
However, weight loss results, side effects, and overall treatment success can vary from person to person
This means GLP-1 agonists like Retatrutide are essentially amplifying a natural gut-to-brain signaling system