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In the SUSTAIN 8 study, patients with T2DM exhibited a lean mass decrease of 2.3 kg alongside a total weight loss of 5.3 kg, resulting in 43.4% of weight loss attributable to lean mass, while the ratio of lean mass to total mass increased by 1.2% from the baseline [111]
Local-Quality Care Without Driving to DFW Many Odessa residents have historically driven 5+ hours to Dallas for specialist care
Combined with the molecular weight argument (semaglutide is too large to easily cross biological barriers into milk) and the poor oral bioavailability (any swallowed semaglutide would be destroyed in the infant gut), the safety profile looks reassuring
When this occurs, it is essential to consider whether the fatigue is genuinely attributable to the GLP-1 medication or whether other factors are contributing
The blood sugar benefits are excellent, and the weight loss is a meaningful bonus that improves overall diabetes management
In fact, cardiovascular disease is the leading cause of death in MASLD patients 3,6
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