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At baseline, eGFR was 90 mL/min/1.73 m2 in 43%, 60 to 90 mL/min/1.73 m2 in 40%, 45 to 60 mL/min/1.73 m2 in 10%, and 30 to 45 mL/min/1.73 m2 in 6% of patients

Another consideration is the impact on blood glucose regulation

severe thiamine deficiency, while rare, can cause Wernickes encephalopathy in hyperemesis gravidarum, and inadequate B is associated with anemia and neurologic issues in the newborn

Are they beyond the pale, or could they still be used potentially

Yes, injections under the skin can be given by the patient themselves

For many patients, seeing daylight between their inner thighs represents both an aesthetic win and the end of uncomfortable chafing