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10.1073/pnas.79.4.1088 Proc

Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo

10 Diabetic retinopathy (DR), occurred in 22% of diabetes patients and 6% suffer from vision threatening DR which might lead to irreversible vision impairment even blindness

HMG-CoA reductase is a key enzyme and regulator of the cholesterol synthesis pathway that catalyzes the conversion of HMG-CoA to mevalonate and ultimately to cholesterol