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The researchers identified two conserved DNA elements in the CHAC1 promoter, ATF/CRE and CARE, which synergistically regulate CHAC1 transcription

Millions of people worldwide deal with knee discomfort that affects their daily activities, from climbing stairs to enjoying recreational sports

Initially, patient concerns were dismissed as mental health problems, including worry or stress [13], but later it became clear that people who suffer from long-term COVID have a wide range of physical and mental symptoms [14,15,16]

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Both PERK and ATF4 were also shown to support autophagy in many hypoxic and nutrient-deprived tumors and cell lines (Rzymski et al

Psychiatry 172 , 10681072 (2015)