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Titrate, dont rush: Nausea, vomiting, diarrhea and constipation are dose-related and amplified by combining an amylin analog with a GLP-1 agonist the four-week steps exist for exactly this reason [1]

[5] However, it is important to emphasise that there is no official link established between GLP-1 agonists and the treatment of rheumatoid arthritis

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