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Ethics declarations Competing interests The results/data/figures in this manuscript have not been published elsewhere, nor are they under consideration by another publisher

Nuclear gene expression reprogramming: metabolism, antioxidation and mitochondrial biosynthesis Mitochondria serve not only as energy hubs but also as sources of diverse metabolic signals that modulate nuclear gene transcription and translation via retrograde signaling, coordinating metabolism and transcription [228]

It can be caused by various factors such as diet, dehydration, lack of physical activity, certain medications, and underlying medical conditions

Lipid extracts were dried under argon gas and resuspended in chloroform at a concentration of 0.5 mg/L based on unprocessed worm pellet weight

Because the peptide is dehydrated, it remains relatively stable when stored correctly

There was no difference in the uptake of the two types of nanocarriers between the healthy control and the PD organoids (Fig