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POMC-derived peptides, particularly -MSH, stimulate MC1R of melanocytes, releasing the intracellular second messenger cAMP, which in turn induces a cascade of intracellular molecular events, ultimately activating the microphthalmia-associated transcription factor (MITF)

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Taken together, the results demonstrated that rifaximin enhanced the inhibitory effects of L-carnitine supplementation on skeletal muscle atrophy in CDAA-fed cirrhotic rats via multifunctional mechanisms based on the modulation of the gut-liver-muscle axis (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] Maeurer MJ, Gollin SM, Storkus WJ, Swaney W, Karbach J, Martin D, Castelli C, Salter R, Knuth A, Lotze MT, 1996