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Metabolism GLP-1 gets rapidly metabolized in the circulation by dipeptidyl peptidase-4 (DPP-IV), resulting in a short plasma half-life of approximately 2 min [11]

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Semaglutide, on the other hand, mimics a hormone called glucagon-like peptide-1 (GLP-1) that signals the brain to reduce appetite, slows food movement through the stomach, and encourages the pancreas to release insulin only when blood sugar rises