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In healthy cells more than 90% of the total GSH pool is in its reduced form [13]

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These include reduced microbial diversity, decreased abundance of beneficial taxa such as Bifidobacterium and Faecalibacterium prausnitzii , and increased representation of pro-inflammatory microbes (Khavandegar et al., 2024

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however, these drugs have been misused Currently available data do not suggest that rhGH treatment should be used to promote longevity Lack of GH action in mouse models is associated with extended longevity, but the mechanism underlying the increased lifespan has yet to be established Given the effects of reduced GH/IGF-1 signalling on lifespan in rodents, decreased GH action might be beneficial for humans, but clinical trials are needed to assess long-term outcome of GH/IGF-1 inhibition This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

The ODT formulation may produce slightly less dramatic results due to lower bioavailability, though individual responses vary considerably