You may have seen microdosing of GLP-1s advertised with promises of fewer side effects and better longevity, though there's no clear scientific definition of microdosing, and we dont yet have data to know if these medications prolong life (except for people with known cardiovascular disease)
Furthermore, our patients often respond positively to 600 mg/day of N-acetylcysteine (NAC), which can decrease elevated levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymes by reducing oxidative stress (Sukumaran et al., 2023)
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Eskelinen MH, Kivipelto M (2010) Caffeine as a protective factor in dementia and Alzheimers disease
Leombruni P et al
Mimicking the Effects of Exercise Since MOTS-c activates many of the same downstream pathways triggered by physical activity, including AMPK signaling, increasing mitochondrial efficiency, and improving fatty acid oxidation, MOTS-c has also been called an exercise mimetic in scientific literature