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Nucleic Acids Res 2011

A nuanced understanding of these interconnected processes is imperative for advancing therapeutic strategies across diverse disease landscapes

Hormonal disorders: Hormonal imbalances due to thyroid disorders, polycystic ovary syndrome, and insulin resistance can trigger melanin production

Avoid tobacco and alcohol: Avoid or limit these substances.

Previous research has demonstrated that TRIM28 facilitates GC deterioration by suppressing PD-L1 ubiquitination and activating the TBKI-IRF1 and TBK1-mTOR signaling pathways, thereby increasing the stability and expression of PD-L1 [28]

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