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Experimental autoimmune encephalomyelitis (EAE) The most popular rodent model of MS employing exogenously-administered myelin antigens together with immune stimulation that replicates some aspects of autoimmune inflammation found in the human disease

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When Keap1 has been inhibited, the activity of Nrf2 increases, resulting in upregulation of the ATP-binding cassette (ABC)-family transporter multidrug resistance protein (MRP1), which prevents GSH efflux from the cell and strongly inhibits ferroptosis ( TABLE 1 NRF2 target genes are involved in regulating ferroptsis

It can lead to anemia, neurological complications, and even death

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