doi: 10.1016/j.ejphar.2015.09.029 67 PajaresMRojo AIMandaGBoscLCuadradoA
The three compounds can be sourced and reconstituted separately, which allows independent dosing but adds cold-chain items and sterile draws
These distinct sequence features may provide the basis for the different structural modules of GLP-1R and GCGR, as well as diverse pathways for conformational change during peptide binding and activation
Feature comparison Mounjaro Also known as tirzepatide Starting from 34/week Expected weight loss 26% Frequency Once weekly Eligibility BMI over 30* Easy to administer Yes In stock Yes Free delivery Yes Learn moreNo Potential side effects Nausea Very common Diarrhoea Very common Vomiting Very common Constipation Very common Headache Common Upset stomach Common Feeling weak or tired Common Dizziness Common Reflux or heartburn Common Gas Common Injection site reaction Common Allergic reaction Common Gallstones Uncommon Hair loss Common Poor sleep No Increased calcitonin levels Uncommon Inflamed gallbladder (cholecystitis) Uncommon Delay in emptying stomach No Acute pancreatitis Uncommon Severe allergic reaction Rare Reduced kidney function No Wegovy Also known as semaglutide Starting from 20/week Expected weight loss 15% Frequency Once weekly Eligibility BMI over 30* Easy to administer Yes In stock Yes Free delivery Yes Learn moreNo Potential side effects Nausea Very common Diarrhoea Very common Vomiting Very common Constipation Very common Headache Very common Upset stomach Very common Feeling weak or tired Very common Dizziness Common Reflux or heartburn Common Gas Common Injection site reaction Common Allergic reaction Common Gallstones Common Hair loss Common Poor sleep No Increased calcitonin levels No Inflamed gallbladder (cholecystitis) No Delay in emptying stomach No Acute pancreatitis Uncommon Severe allergic reaction Rare Reduced kidney function No Saxenda Also known as liraglutide Starting from 55/pen Expected weight loss 10% Frequency Once daily Eligibility BMI over 30* Easy to administer Yes In stock Yes Free delivery Yes Learn moreNo Potential side effects Nausea Very common Diarrhoea Very common Vomiting Very common Constipation Very common Headache Very common Upset stomach Common Feeling weak or tired Common Dizziness Common Reflux or heartburn Common Gas Common Injection site reaction Common Allergic reaction Common Gallstones Common Hair loss No Poor sleep Common Increased calcitonin levels No Inflamed gallbladder (cholecystitis) Uncommon Delay in emptying stomach Uncommon Acute pancreatitis Rare Severe allergic reaction Rare Reduced kidney function Rare Feature comparison Potential side effects *BMI over 27 if you have a weight related condition such as dysglycaemia (prediabetes or type 2 diabetes mellitus), hypertension, dyslipidaemia, or obstructive sleep apnoea
Users experience reductions in blood pressure, triglyceride levels, and markers of systemic inflammation
Expect to submit PAs for GLP-1s
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