Its protective effects are closely related to the inhibition of ferroptosis: Irisin can reverse the oxidative stress imbalance caused by sepsis, lower ROS and Fe 2+ levels in the lung, and downregulate the expression of ferroptosis-related markers (ACSL4, Ptgs2, and Hspa5) and proteins (ACSL4, COX-2, and p-AMPK), thereby exerting lung-protective effects (Zhang F
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The lack of preservative means bacterial growth risk increases rapidly
Metabolism 99:2531