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The results of the studies demonstrated that VPA and its therapeutic metabolites promote the phenotypic shift of microglia from the M1 phenotype to the M2 phenotype and inhibited microglial activation, thereby reducing the level of pro-inflammatory factors caused by spinal cord injury

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The STAT6-ANGPTL4 axis may be directly or indirectly associated with activation of the cGAS-STING pathway, macrophage polarization, and macrophage-to-mesenchymal transition in the diabetic kidney, thereby promoting renal fibrosis