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10.1002/syn.21793 245 SarkarC.ChandraG.PengS.ZhangZ.LiuA.MukherjeeA

Others do better with moderate carbohydrate

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Documented Long-Term Side Effects of Opioids Chronic or recurrent opioid use has been associated with: Central nervous system suppression , affecting alertness, coordination, and mood (35,36) Disrupted gut motility and microbiome balance , contributing to constipation, dysbiosis, and inflammation (38) Hormonal suppression , including reduced testosterone, altered HPA-axis signaling, and downstream endocrine disruption, which can worsen fatigue, depression, and pain perception (34) Impaired immune function , increasing susceptibility to infection (37) Reduced motivation and physical activity , slowing rehabilitation and tissue recovery (35) Why Opioids May Worsen Chronic Pain Over Time Because opioids suppress pain perception without addressing inflammatory, structural, or metabolic drivers, symptoms often return when doses declinefrequently with heightened sensitivity due to opioid-induced hyperalgesia

Women who are pregnant or planning to become pregnant should avoid this medication unless clearly needed, due to unknown fetal risks

If you are taking it for skin-related goals, you may need to wait closer to 12 weeks to see visible shifts in radiance or tone