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Founder pups were genotyped as described below and backcrossed to C57BL/6J mice for at least four generations before experimentation

A 2024 observational study in adults without diabetes found 6% mean weight loss over 12 weeks at 0.251.0 mg/week semaglutide, with mostly mild, transient GI symptoms

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Rani Therapeutics Announces Preclinical Data Demonstrating Successful Oral Delivery of Semaglutide via RaniPill HC - Oral semaglutide administered via the RaniPill HC (RT-116) demonstrated comparable bioavailability, pharmacokinetics and weight loss to subcutaneous administration - - RT-116 was well tolerated with no serious adverse events - - Data adds to growing body of evidence of the RaniPill platforms potential to enable oral delivery of multiple obesity treatments - - Phase 1 study for RT-114, an oral GLP-1/GLP-2 dual agonist for the treatment of obesity, expected to initiate in 2025 - SAN JOSE, Calif., Feb

Limited genetic susceptibility to severe Graves ophthalmopathy: no role for CTLA-4 but evidence for an environmental etiology