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Curr Med Res Opin (2011) 27(3):54758

Activation of these receptors triggers intracellular signaling through Gs-coupled pathways that stimulate adenylate cyclase and increase intracellular cyclic AMP concentrations

however, no significant differences in eGFR decline were identified in any of the treatment groups [44]

The answer depends on where you stand right now, what your goals are, and how much patience you have

Individuals stop the medication for reasons including high cost, unwanted side effects, or achieving their weight loss goals

Or the Phase 2b result may have been partially driven by chance variation in a relatively small sample