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Neurobiol Dis 170:105766 Hoglund E, Overli O, Winberg S (2019) Tryptophan metabolic pathways and brain serotonergic activity: a comparative review
Ma J, Liu Y, Guo Y et al (2021) Transcriptional profiling of aflatoxin B1-induced oxidative stress and inflammatory response in macrophages
Published binding studies have demonstrated 10-100 fold increased potency compared to native alpha-MSH at the MC1R
Rodent wound-healing biology, copper handling, and dose scaling do not translate one-to-one to humans, and effects seen in a rat wound chamber cannot be assumed to occur, at the same magnitude or at all, in a person
Nevertheless, the clinical application of multi-receptor agonists in adolescents requires caution, as long-term safety, developmental outcomes, and real-world adherence data in pediatric populations are still lacking