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Freeze-drying removes all water, leaving a stable powder that can survive shipping and months of shelf storage without losing potency

The standard schedule is a starting point, not a strict rule The 2024 NICE guideline NG239 on B12 deficiency in over 16s makes an important point: the optimal route, dose and frequency of B12 replacement have never been firmly established, and have often followed custom and historical practice

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MiR-145, a well-known tumor suppressor miRNA, is substantially downregulated in tumor tissues relative to their equivalent normal tissues in prostate and breast cancer [117]