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doi: 10.1016/j.bcp.2022.115322

Given variability in response, genotype-guided selection may identify subgroups most likely to benefit

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In conclusion, we show that chronic in vivo GSH deficiency, despite inducing CYP2E1 and hepatic oxidative stress, triggers adaptive mechanisms that protect the liver against ethanol-induced toxicity

[13] [15] There is a risk of oxalate nephropathy or kidney stone formation, particularly in patients with pre-existing renal impairment or those receiving prolonged high-dose therapy

Protocols describe pulling the vial out, drawing the dose, and returning it to the refrigerator rather than leaving it on the counter during prep