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Studies on opioids have yielded mixed results, with some reporting a decrease in opioid self-administration with GLP-1 receptor agonist treatment, while others have found no significant effects

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For example, one case described at the Mayo Clinic showed that repeated VAX-D sessions caused a spinal disc to enlarge suddenly, which worsened the patients pain and required surgery to correct (McMillin & Sherry, 2002)

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The incidence of galactorrhea in men with hyperprolactinemia is low, less than 30% (i.e., it is much less common than in women)