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H., Dee, P
It is important to note that weight loss results can vary depending on the type of drug you take and your prescribed dose
In a phase 1 trial by Martin and colleagues, observations at week 6 comparing tirzepatide vs once-daily liraglutide and placebo have shown that the use of the latter, provides a reduction on the desire for high-fat and high-sugar food by lowering activation in the cingulate gyri, hippocampus and orbitofrontal cortex assessed by MRI and blood-oxygen-level at these areas, meaning less appetite, early satiety, and less food craving with more reduction on weight loss at short term (181)
Many people with obesity already carry internalized shame and guilt, and while GLP-1s may provide a solution to obesity, they dont come without stigmas of their own
Semaglutide, a type of GLP-1R agonists with 94% sequence homology to GLP-1 and with an extended half-life of approximately 1 week, has been clinically approved to treat T2DM and is available in subcutaneous and oral dosage form (136, 137)
De Giorgi R, Ghenciulescu A, Yotter C, Taquet M, Koychev I (2025) Glucagon-like peptide-1 receptor agonists for major neurocognitive disorders
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